Centre for Integrative Genetics (CIGENE)

The principal objectives of work package 3 are to establish a generic yeast model population for the genetics community, document that the quantitative genetics behaviour of this population is in accordance with the genetics of higher eukaryotes, and use the model population together with ultra-high-throughput sequencing and new bioinformatics software to study key theoretical issues associated with the genotype-phenotype map.

We want to make use of the yeast population described above to investigate the causes of change in genetic variation. What is the relative importance of mutation, recombination, selection, and inbreeding for the genetic variance in the yeast populations formed? Long term selection experiments have shown that genetic gain continues for very many generations, meaning that genetic variation is not exhausted as one might expect if gene actions were additive and numbers of genes limited. We thus have to assure that our experimental population reflects the quantitative genetics observations made in higher eukaryotes before we can start to address our main scientific goals
(3)

• Stig W. Omholt
• Arne Gjuvsland
• Enikö Zörgö
• Jonas Warringer
• Jeevan Karloss

Collaborators

• Anders Blomberg
• Inge Jonassen
• Pål Puntervoll