Time: October 5th, 14.00
Place: The Biotechnology building library (ground floor), UMB
Saccharomyces cerevisiae is commonly used for aging research and has played a central role in the identification of the conserved pathways that regulate aging in organisms ranging from yeast to mammals. Thanks to its amenability to genomic analysis S. cerevisiae is providing an excellent tool to identify novel life span regulators and to gain further insights into the aging process that may be relevant to human aging. Paola Fabrizio will present an overview of the mechanisms involved in longevity extension in yeast with particular emphasis on those implicating cellular protection, metabolic switches, and genomic stability. She will also present some recent results relative to the identification of novel genes involved in life span regulation by a genome-wide screen of the yeast deletion collection.
Paola Fabrizio is currently a research scientist with CNRS located in Lyon, France. (Centre national de la recherche scientifique - National Centre of Scientific Research, the largest governmental research organization in France and the largest fundamental science agency in Europe). Her current research interests include:
- Role of epigenetic modifications in the regulation of yeast aging and genomic instability.
- Biology of Aging: Identification of conserved molecular pathways/ mechanisms that regulate aging, stress resistance, and genomic instability in Saccharomyces cerevisiae and C. elegans.
- The genetics of dietary restriction.
- Role of superoxide in yeast aging, apoptosis, and adaptive regrowth.
- Yeast adaptive regrowth as a model for dedifferentiation and cancer.
- Functional Genomics: analysis of gene expression profiles of wild type and long-lived yeast. Use of yeast gene-deletion collection and tag arrays for the identification of novel long-lived mutants.
