Leif Andersson, Professor at the Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, will give a talk for all those interested on Wednesday 22 November, 12.15-13.00, in room H185, Animal Science Building, UMB.
Leif Andersson |
Domestic animals provide unique opportunities for exploring genotype-phenotype relationships for several reasons. Firstly, selective breeding during thousands of years has enriched for mutations that have adapted the domestic animals to a new environment, i.e. farming under various environmental conditions. Secondly, the population structure is often favorable for genetic studies, large families and more or less closely related subpopulations (breeds). Thirdly, strong selection leaves genomic footprints that facilitate positional cloning. The development of draft genome sequences and high-density SNP maps now allow us to fully exploit the potential of domestic animals as a model for advancing our understanding of biology. The combined use of linkage mapping and linkage disequilibrium (LD) mapping within and between breeds provides a powerful approach for positional identification of both monogenic and multifactorial trait loci. The successful use of this approach for identifying genes underlying phenotypic traits will be illustrated on the basis of our research program in chicken, pig, dog and horse.
For information on Prof. Andersson and his work, please see this
link.
