Østby, Ivar

Postdoc

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Phone: +47-6496-5269

Present positions: Post.doc. fellow at the Norwegian University of Life Sciences (UMB), Centre for Integrative Genetics (CIGENE)

Degrees: Dr. Scient. in applied mathematics/medical informatics, University of Oslo (UiO)

Professional background: Teacher in mathematics, physics, informatics, German (1973-1997); Research assistant , Department of Plant Research, Norwegian Agricultural University (presently UMB) (1998-1999); Research fellow, University of Oslo (1999-2003).
 
Research experience: Data-driven mathematical modelling of biophysical processes: maturation of human granulocytes during high dose chemotherapy with stem cell support, bystander effect during cancer development, ion and water dynamics in mammal brain astrocytes.

Relevant recent activity: Development of extensive models of ion and water dynamics in mammal brain astrocytes and extracellular space.

Selected publications:
  • Mathematical modeling of human granulopoiesis: the possible importance of regulated apoptosis. Ivar Østby, Haakon B. Benestad, Per Grøttum. Mathematical Biosciences  2003;186:1-27, DOI: 10.1016/j.mbs.2003.07.003.
  • A mathematical model for reconstitution of granulopoiesis after high dose chemotherapy with autologous stem cell transplantation.Ivar Østby, Leiv S. Rusten, Gunnar Kvalheim, Per Grøttum. Journal of Mathematical Biology 2003;47:101-136, DOI: 10.1007/s00285-003-0198-6.
  • Mathematical modeling of granulocyte reconstitution after high dose chemotherapy with stem cell support. Effect of post transplant G-CSF treatment. Ivar Østby, Gunnar Kvalheim, Leiv S. Rusten, Per Grøttum. Journal of Theoretical Biology 2004 Nov 7;231(1):69-83, DOI: 10.1016/j.jtbi.2004.05.010.
  • Stability of a model of human granulopoiesis using continuous maturation.Ivar Østby, Ragnar Winther. Journal of Mathematical Biology 2004;49:501-536., DOI:10.1007/s00285-004-0274-6.
  • A model for reconstitution of granulopoiesis after high dose chemotherapy. Ivar Østby, Leiv S. Rusten, Gunnar Kvalheim, Per Grøttum. Proceedings, Nordic MATLAB Conference, 21-22 October 2003.
  • A stochastic model of  cancer initiation including a bystander effect. Ivar Østby, Leiv Øyehaug, Harald B. Steen. Journal of Theoretical Biology 2006;241:751-764., DOI: 10.1016/j.jtbi.2006.01.013.
  • Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. Ivar Østby, Leiv Øyehaug, Gaute T. Einevoll, Erlend A. Nagelhus, Erik Plahte, Thomas Zeuthen, Catherine M. Lloyd, Ole P. Ottersen, Stig W. Omholt. PLoS Computational Biology 2009; 5(1):1-12.