Background: The main methods for analyzing the relation between genotype and phenotypes, such as association studies, are based on linear models. These models were introduced long before the establishment of molecular biology, and need to be complemented by models emphasizing how genes act and interact. The emerging branch of genetics called "systems genetics" covers a range of network methods to describe the relationship between genotypes and layers of phenotypes, ranging from the transcriptome and proteome up to higher-level physiological traits. The methods employed include multivariate methods for discovering correlation networks in –omics data, coarse-grained methods such as Bayesian networks and structural equations for learning causal networks, and non-linear dynamic models that explicitly represent process rates as a function of state. This workshop is intended to promote the exchange of perspectives and different angles of approach in systems genetics, and we believe it will stimulate novel work for everybody attending. The workshop is open for master and PhD students, postdocs and researchers.
Date/venue (NB! Change of venue from previously announced): Friday 12th October 09.45 – 15.30, SKP auditorium, Syverudveien 6, UMB Campus Ås (building no. 61 on this map).
09.45 – 10.00: Registration and coffee
10.00 – 10.10: Welcome
Stig W. Omholt, Norwegian University of Life Sciences/CIGENE.
10.10 – 10.50: Linking genomic sequence to organismal development.
Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford.
10.50 – 11.30: Factors that shape the genotype-phenotype map.
Scott Rifkin, Section of Ecology, Behavior, and Evolution, University of California, San Diego.
11.30 – 12.30: Lunch
12.30 – 13.10: The biology of individuals: why would a mutation kill me, but not you?
Ben Lehner, Center for Genomic Regulation, Barcelona.
13.10 – 13.50: A monotone talk on genotype-phenotype maps
Arne B. Gjuvsland, Norwegian University of Life Sciences/CIGENE.
13.50 – 14.10: Coffee
14.10 – 14.50: Model repositories and broad-scale genotype-phenotype model studies.
Jon Olav Vik, Norwegian University of Life Sciences/CIGENE.
14.50 – 15.20: Discussion
15.20 – 15.30: Closing remarks
Please register for the workshop by sending an e-mail to Barbara Eriksen by Wednesday 3rd October, including your first and family name, e-mail address, affiliation and position (master or PhD student, postdoc, researcher, etc.) There is no registration fee, but please regard your registration as binding for planning purposes.